Tottenham striker Harry Kane left White Hart Lane on crutches and in a protective boot after suffering an ankle problem in Spurs’ 6-0 FA Cup quarter-final win over Millwall.
The England forward limped off early in the piece after appearing to get his leg trapped underneath Lions defender Jake Cooper in the act of shooting at goal.
Spurs boss Mauricio Pochettino conceded the injury looked ‘similar’ to the one Kane suffered at Sunderland in September which kept him sidelined for two months.
“He twists his ankle – the same ankle as it was before against Sunderland,” Pochettino said. “Now we will wait and assess tomorrow and wait and see.
“Today it’s difficult. It’s a similar situation to Sunderland. We need to assess him today it is difficult to give you a real level of how he is.
“We hope it’s not a big issue but it looks similar. It’s sure it will be difficult for him to play against Southampton but we need to see what happens in the next few days.
“Every time something like this happens and before the scan he immobilises with a [protective] boot.”
Kane will undergo a scan on Monday ahead of Gareth Southgate’s England squad announcement later next week.
Spurs were not disrupted by the loss of their skipper on the day, thumping six past their League One opponents.
Heung-Min Son hit a hat-trick with Eriksen, Dele Alli and Vincent Janssen, who scored his first goal from open play in a Tottenham shirt, also finding the net.