The former Everton midfielder, who is currently a free agent, was speaking about the quarter-final clash on BBC’s Match of the Day when he was asked for his opinion on a comment made by Graeme Souness.
Looking ahead at the fixture, the Scottish pundit said there is no chance Jose Mourinho’s men will be able to get a result over the team he used to manage.
Souness explained that Chelsea will be buoyed by the absence of Zlatan Ibrahimovic, whose three-match ban prevents him from playing.
And said he expects the Blues, who are currently ten points clear at the top of the Premier League, to progress to the semi-finals with any problems.
Osman agreed with his comment, adding: “He [Ibrahimovic] has been such a figurehead for them this season.
“[He’s] scored probably 40 per cent of all their goals, he is also assisting them, he’s just a big physical presence up there.”
“And I think they will really miss him, and with Chelsea being so strong – especially with them at home – I just can’t see anything but a Chelsea win.”